Drug repositioning for Alzheimer's disease
Identifieur interne : 000062 ( Main/Exploration ); précédent : 000061; suivant : 000063Drug repositioning for Alzheimer's disease
Auteurs : Anne Corbett [Royaume-Uni] ; James Pickett [Royaume-Uni] ; Alistair Burns [Royaume-Uni] ; Jonathan Corcoran [Royaume-Uni] ; Stephen B. Dunnett [Royaume-Uni] ; Paul Edison [Royaume-Uni] ; Jim J. Hagan [Royaume-Uni] ; Clive Holmes [Royaume-Uni] ; Emma Jones [Royaume-Uni] ; Cornelius Katona [Royaume-Uni] ; Ian Kearns [Royaume-Uni] ; Patrick Kehoe [Royaume-Uni] ; Amrit Mudher [Royaume-Uni] ; Anthony Passmore [Royaume-Uni] ; Nicola Shepherd [Royaume-Uni] ; Frank Walsh [Royaume-Uni] ; Clive Ballard [Royaume-Uni]Source :
- Nature Reviews Drug Discovery [ 1474-1776 ] ; 2012-11.
Abstract
Existing drugs for Alzheimer's disease provide symptomatic benefit for up to 12 months, but there are no approved disease-modifying therapies. Given the recent failures of various novel disease-modifying therapies in clinical trials, a complementary strategy based on repositioning drugs that are approved for other indications could be attractive. Indeed, a substantial body of preclinical work indicates that several classes of such drugs have potentially beneficial effects on Alzheimer's-like brain pathology, and for some drugs the evidence is also supported by epidemiological data or preliminary clinical trials. Here, we present a formal consensus evaluation of these opportunities, based on a systematic review of published literature. We highlight several compounds for which sufficient evidence is available to encourage further investigation to clarify an optimal dose and consider progression to clinical trials in patients with Alzheimer's disease.
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DOI: 10.1038/nrd3869
Affiliations:
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Drug repositioning for Alzheimer's disease</title><author><name sortKey="Corbett, Anne" sort="Corbett, Anne" uniqKey="Corbett A" first="Anne" last="Corbett">Anne Corbett</name></author><author><name sortKey="Pickett, James" sort="Pickett, James" uniqKey="Pickett J" first="James" last="Pickett">James Pickett</name></author><author><name sortKey="Burns, Alistair" sort="Burns, Alistair" uniqKey="Burns A" first="Alistair" last="Burns">Alistair Burns</name></author><author><name sortKey="Corcoran, Jonathan" sort="Corcoran, Jonathan" uniqKey="Corcoran J" first="Jonathan" last="Corcoran">Jonathan Corcoran</name></author><author><name sortKey="Dunnett, Stephen B" sort="Dunnett, Stephen B" uniqKey="Dunnett S" first="Stephen B." last="Dunnett">Stephen B. Dunnett</name></author><author><name sortKey="Edison, Paul" sort="Edison, Paul" uniqKey="Edison P" first="Paul" last="Edison">Paul Edison</name></author><author><name sortKey="Hagan, Jim J" sort="Hagan, Jim J" uniqKey="Hagan J" first="Jim J." last="Hagan">Jim J. Hagan</name></author><author><name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name></author><author><name sortKey="Jones, Emma" sort="Jones, Emma" uniqKey="Jones E" first="Emma" last="Jones">Emma Jones</name></author><author><name sortKey="Katona, Cornelius" sort="Katona, Cornelius" uniqKey="Katona C" first="Cornelius" last="Katona">Cornelius Katona</name></author><author><name sortKey="Kearns, Ian" sort="Kearns, Ian" uniqKey="Kearns I" first="Ian" last="Kearns">Ian Kearns</name></author><author><name sortKey="Kehoe, Patrick" sort="Kehoe, Patrick" uniqKey="Kehoe P" first="Patrick" last="Kehoe">Patrick Kehoe</name></author><author><name sortKey="Mudher, Amrit" sort="Mudher, Amrit" uniqKey="Mudher A" first="Amrit" last="Mudher">Amrit Mudher</name></author><author><name sortKey="Passmore, Anthony" sort="Passmore, Anthony" uniqKey="Passmore A" first="Anthony" last="Passmore">Anthony Passmore</name></author><author><name sortKey="Shepherd, Nicola" sort="Shepherd, Nicola" uniqKey="Shepherd N" first="Nicola" last="Shepherd">Nicola Shepherd</name></author><author><name sortKey="Walsh, Frank" sort="Walsh, Frank" uniqKey="Walsh F" first="Frank" last="Walsh">Frank Walsh</name></author><author><name sortKey="Ballard, Clive" sort="Ballard, Clive" uniqKey="Ballard C" first="Clive" last="Ballard">Clive Ballard</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6A37E13CBEAD425373FA2EBBB3598916D2A6A7DB</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1038/nrd3869</idno><idno type="url">https://api.istex.fr/document/6A37E13CBEAD425373FA2EBBB3598916D2A6A7DB/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000506</idno><idno type="wicri:Area/Main/Curation">000438</idno><idno type="wicri:Area/Main/Exploration">000062</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Drug repositioning for Alzheimer's disease</title><author><name sortKey="Corbett, Anne" sort="Corbett, Anne" uniqKey="Corbett A" first="Anne" last="Corbett">Anne Corbett</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Anne Corbett and Clive Ballard are at the Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL</wicri:regionArea><wicri:noRegion>London SE1 1UL</wicri:noRegion></affiliation><affiliation><wicri:noCountry code="no comma">A.C. and J.P. contributed equally to this work.</wicri:noCountry></affiliation></author><author><name sortKey="Pickett, James" sort="Pickett, James" uniqKey="Pickett J" first="James" last="Pickett">James Pickett</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>James Pickett is at the UK Alzheimer's Society, Devon House, 58 St Katharine's Way, London E1W 1LB</wicri:regionArea><wicri:noRegion>London E1W 1LB</wicri:noRegion></affiliation><affiliation><wicri:noCountry code="no comma">A.C. and J.P. contributed equally to this work.</wicri:noCountry></affiliation></author><author><name sortKey="Burns, Alistair" sort="Burns, Alistair" uniqKey="Burns A" first="Alistair" last="Burns">Alistair Burns</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Alistair Burns is at the University of Manchester, Oxford Road, Manchester M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Corcoran, Jonathan" sort="Corcoran, Jonathan" uniqKey="Corcoran J" first="Jonathan" last="Corcoran">Jonathan Corcoran</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Jonathan Corcoran and Emma Jones are at the Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College London, London SE1 1UL</wicri:regionArea><wicri:noRegion>London SE1 1UL</wicri:noRegion></affiliation></author><author><name sortKey="Dunnett, Stephen B" sort="Dunnett, Stephen B" uniqKey="Dunnett S" first="Stephen B." last="Dunnett">Stephen B. Dunnett</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Stephen B. Dunnett is at the Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX</wicri:regionArea><wicri:noRegion>Cardiff CF10 3AX</wicri:noRegion></affiliation></author><author><name sortKey="Edison, Paul" sort="Edison, Paul" uniqKey="Edison P" first="Paul" last="Edison">Paul Edison</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Paul Edison is at Imperial College London, Cyclotron building, Hammersmith Campus, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation></author><author><name sortKey="Hagan, Jim J" sort="Hagan, Jim J" uniqKey="Hagan J" first="Jim J." last="Hagan">Jim J. Hagan</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Jim J. Hagan is at the Global Medical Excellence Cluster (GMEC), Hodgkin Building, Guy's Campus, King's College London, London SE1 1UL</wicri:regionArea><wicri:noRegion>London SE1 1UL</wicri:noRegion></affiliation></author><author><name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Clive Holmes is at the University of Southampton, Southampton General Hospital, Mailpoint 801, South Academic Block, Tremona Road, Southampton SO16 6YD</wicri:regionArea><wicri:noRegion>Southampton SO16 6YD</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Emma" sort="Jones, Emma" uniqKey="Jones E" first="Emma" last="Jones">Emma Jones</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Jonathan Corcoran and Emma Jones are at the Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College London, London SE1 1UL</wicri:regionArea><wicri:noRegion>London SE1 1UL</wicri:noRegion></affiliation></author><author><name sortKey="Katona, Cornelius" sort="Katona, Cornelius" uniqKey="Katona C" first="Cornelius" last="Katona">Cornelius Katona</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Cornelius Katona is at University College London, Mental Health Sciences Unit, Faculty of Brain Sciences, London WC1E 6BT</wicri:regionArea><wicri:noRegion>London WC1E 6BT</wicri:noRegion></affiliation></author><author><name sortKey="Kearns, Ian" sort="Kearns, Ian" uniqKey="Kearns I" first="Ian" last="Kearns">Ian Kearns</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Ian Kearns is at AstraZeneca, 2 Kingdom Street, London W2 6BD</wicri:regionArea><wicri:noRegion>London W2 6BD</wicri:noRegion></affiliation></author><author><name sortKey="Kehoe, Patrick" sort="Kehoe, Patrick" uniqKey="Kehoe P" first="Patrick" last="Kehoe">Patrick Kehoe</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Patrick Kehoe is at the University of Bristol, John James Laboratories, Frenchay Hospital, Bristol BS16 1LE</wicri:regionArea><wicri:noRegion>Bristol BS16 1LE</wicri:noRegion></affiliation></author><author><name sortKey="Mudher, Amrit" sort="Mudher, Amrit" uniqKey="Mudher A" first="Amrit" last="Mudher">Amrit Mudher</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Amrit Mudher is at the University of Southampton, Life Sciences Building 85, University Road, Southampton SO17 1BJ</wicri:regionArea><wicri:noRegion>Southampton SO17 1BJ</wicri:noRegion></affiliation></author><author><name sortKey="Passmore, Anthony" sort="Passmore, Anthony" uniqKey="Passmore A" first="Anthony" last="Passmore">Anthony Passmore</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Anthony Passmore is at Queen's University Belfast, Centre for Public Health, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL</wicri:regionArea><wicri:noRegion>Belfast BT9 7BL</wicri:noRegion></affiliation></author><author><name sortKey="Shepherd, Nicola" sort="Shepherd, Nicola" uniqKey="Shepherd N" first="Nicola" last="Shepherd">Nicola Shepherd</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Nicola Shepherd is at the Wellcome Trust, Gibbs Building, 215 Euston Road, London NW1 2BE</wicri:regionArea><wicri:noRegion>London NW1 2BE</wicri:noRegion></affiliation></author><author><name sortKey="Walsh, Frank" sort="Walsh, Frank" uniqKey="Walsh F" first="Frank" last="Walsh">Frank Walsh</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Frank Walsh is at the Institute of Psychiatry, King's College London, London SE1 1UL</wicri:regionArea><wicri:noRegion>London SE1 1UL</wicri:noRegion></affiliation></author><author><name sortKey="Ballard, Clive" sort="Ballard, Clive" uniqKey="Ballard C" first="Clive" last="Ballard">Clive Ballard</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Anne Corbett and Clive Ballard are at the Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL</wicri:regionArea><wicri:noRegion>London SE1 1UL</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Nature Reviews Drug Discovery</title><idno type="ISSN">1474-1776</idno><idno type="eISSN">1474-1784</idno><imprint><publisher>Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</publisher><date type="published" when="2012-11">2012-11</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="833">833</biblScope><biblScope unit="page" to="846">846</biblScope></imprint><idno type="ISSN">1474-1776</idno></series><idno type="istex">6A37E13CBEAD425373FA2EBBB3598916D2A6A7DB</idno><idno type="DOI">10.1038/nrd3869</idno><idno type="ArticleID">nrd3869</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1474-1776</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">Existing drugs for Alzheimer's disease provide symptomatic benefit for up to 12 months, but there are no approved disease-modifying therapies. Given the recent failures of various novel disease-modifying therapies in clinical trials, a complementary strategy based on repositioning drugs that are approved for other indications could be attractive. Indeed, a substantial body of preclinical work indicates that several classes of such drugs have potentially beneficial effects on Alzheimer's-like brain pathology, and for some drugs the evidence is also supported by epidemiological data or preliminary clinical trials. Here, we present a formal consensus evaluation of these opportunities, based on a systematic review of published literature. We highlight several compounds for which sufficient evidence is available to encourage further investigation to clarify an optimal dose and consider progression to clinical trials in patients with Alzheimer's disease.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Manchester</li></region><settlement><li>Manchester</li></settlement><orgName><li>Université de Manchester</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Corbett, Anne" sort="Corbett, Anne" uniqKey="Corbett A" first="Anne" last="Corbett">Anne Corbett</name></noRegion><name sortKey="Ballard, Clive" sort="Ballard, Clive" uniqKey="Ballard C" first="Clive" last="Ballard">Clive Ballard</name><name sortKey="Ballard, Clive" sort="Ballard, Clive" uniqKey="Ballard C" first="Clive" last="Ballard">Clive Ballard</name><name sortKey="Burns, Alistair" sort="Burns, Alistair" uniqKey="Burns A" first="Alistair" last="Burns">Alistair Burns</name><name sortKey="Corcoran, Jonathan" sort="Corcoran, Jonathan" uniqKey="Corcoran J" first="Jonathan" last="Corcoran">Jonathan Corcoran</name><name sortKey="Dunnett, Stephen B" sort="Dunnett, Stephen B" uniqKey="Dunnett S" first="Stephen B." last="Dunnett">Stephen B. Dunnett</name><name sortKey="Edison, Paul" sort="Edison, Paul" uniqKey="Edison P" first="Paul" last="Edison">Paul Edison</name><name sortKey="Hagan, Jim J" sort="Hagan, Jim J" uniqKey="Hagan J" first="Jim J." last="Hagan">Jim J. Hagan</name><name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name><name sortKey="Jones, Emma" sort="Jones, Emma" uniqKey="Jones E" first="Emma" last="Jones">Emma Jones</name><name sortKey="Katona, Cornelius" sort="Katona, Cornelius" uniqKey="Katona C" first="Cornelius" last="Katona">Cornelius Katona</name><name sortKey="Kearns, Ian" sort="Kearns, Ian" uniqKey="Kearns I" first="Ian" last="Kearns">Ian Kearns</name><name sortKey="Kehoe, Patrick" sort="Kehoe, Patrick" uniqKey="Kehoe P" first="Patrick" last="Kehoe">Patrick Kehoe</name><name sortKey="Mudher, Amrit" sort="Mudher, Amrit" uniqKey="Mudher A" first="Amrit" last="Mudher">Amrit Mudher</name><name sortKey="Passmore, Anthony" sort="Passmore, Anthony" uniqKey="Passmore A" first="Anthony" last="Passmore">Anthony Passmore</name><name sortKey="Pickett, James" sort="Pickett, James" uniqKey="Pickett J" first="James" last="Pickett">James Pickett</name><name sortKey="Shepherd, Nicola" sort="Shepherd, Nicola" uniqKey="Shepherd N" first="Nicola" last="Shepherd">Nicola Shepherd</name><name sortKey="Walsh, Frank" sort="Walsh, Frank" uniqKey="Walsh F" first="Frank" last="Walsh">Frank Walsh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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